LEVERAGING A NATIONAL AMBULATORY CARE CLINIC NETWORK FOR REAL-WORLD EVIDENCE: INSIGHTS FROM A LARGE US EHR DATASET
Author(s)
Dingwei Dai, PhD, MD1, Sravanthi Mikkilineni, MS1, Raman Kumar, MS1, Joaquim Fernandes, MS1, Sheila Thomas, PharmD1, David Fairchild, MD2;
1CVS Healthspire™ Life Sciences Solutions, Woonsocket, RI, USA, 2CVS Health, Woonsocket, RI, USA
1CVS Healthspire™ Life Sciences Solutions, Woonsocket, RI, USA, 2CVS Health, Woonsocket, RI, USA
Presentation Documents
OBJECTIVES: A national network of ambulatory care clinics operates over 800 sites across the US, providing care for minor illnesses and injuries, chronic condition monitoring, immunizations, annual physical exams, and blood work. This study describes the scope and utility of network-wide electronic health records (EHRs) for epidemiology and outcomes research.
METHODS: Network-wide EHRs contain longitudinal, patient-level data collected during routine care, including demographics, diagnoses, procedures, medications, laboratory results, pathology reports, imaging, vital signs, and clinical notes. Data are available from October 2014 onward. Common diagnoses, procedures, and vaccinations were summarized for 2023.
RESULTS: In 2023, 2,651,333 patients (62.9% female; mean age 36.8 years) accounted for 3,429,690 visits. Most had commercial insurance (77.8%), and racial distribution was 65.7% White, 11.5% Hispanic, 8% Black, and 5.5% Asian. The mean Social Vulnerability Index was 0.38. Top diagnoses included acute pharyngitis (10.4%), streptococcal sore throat (4.7%), upper respiratory infection (4%), and acute pansinusitis (3.4%). Common procedures were COVID-19 testing (22.6%), strep point-of -care testing (POCT) (17.5%), and urine dipstick POCT (4.3%). A total of 1,280,114 vaccines were administered, primarily influenza (571,671), COVID-19 (184,870), diphtheria, tetanus, and acellular pertussis booster vaccine (Tdap, 138,830), herpes zoster (72,115), and hepatitis B (61,257). Several outcomes research studies have been conducted using the EHRs, including analyses on the impact of vaccination and nirmatrelvir/ritonavir on the economic burden of COVID-19, as well as the impact of COVID-19 on health-related quality of life.
CONCLUSIONS: EHRs from a national network of ambulatory care clinics provide a comprehensive, granular dataset for real-world evidence research, enabling analysis of healthcare resource utilization, registries, and longitudinal studies. Their ability to link with healthcare claims and mortality data further supports evaluations of health programs, policies, and both economic and clinical outcomes.
METHODS: Network-wide EHRs contain longitudinal, patient-level data collected during routine care, including demographics, diagnoses, procedures, medications, laboratory results, pathology reports, imaging, vital signs, and clinical notes. Data are available from October 2014 onward. Common diagnoses, procedures, and vaccinations were summarized for 2023.
RESULTS: In 2023, 2,651,333 patients (62.9% female; mean age 36.8 years) accounted for 3,429,690 visits. Most had commercial insurance (77.8%), and racial distribution was 65.7% White, 11.5% Hispanic, 8% Black, and 5.5% Asian. The mean Social Vulnerability Index was 0.38. Top diagnoses included acute pharyngitis (10.4%), streptococcal sore throat (4.7%), upper respiratory infection (4%), and acute pansinusitis (3.4%). Common procedures were COVID-19 testing (22.6%), strep point-of -care testing (POCT) (17.5%), and urine dipstick POCT (4.3%). A total of 1,280,114 vaccines were administered, primarily influenza (571,671), COVID-19 (184,870), diphtheria, tetanus, and acellular pertussis booster vaccine (Tdap, 138,830), herpes zoster (72,115), and hepatitis B (61,257). Several outcomes research studies have been conducted using the EHRs, including analyses on the impact of vaccination and nirmatrelvir/ritonavir on the economic burden of COVID-19, as well as the impact of COVID-19 on health-related quality of life.
CONCLUSIONS: EHRs from a national network of ambulatory care clinics provide a comprehensive, granular dataset for real-world evidence research, enabling analysis of healthcare resource utilization, registries, and longitudinal studies. Their ability to link with healthcare claims and mortality data further supports evaluations of health programs, policies, and both economic and clinical outcomes.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
RWD66
Topic
Real World Data & Information Systems
Disease
SDC: Diabetes/Endocrine/Metabolic Disorders (including obesity), SDC: Infectious Disease (non-vaccine), SDC: Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory), STA: Vaccines