Presentation (CTI)

OBJECTIVES: To systematically compare, review, and evaluate the quality of content in domains related to health-related quality of life (HRQOL) covered by instruments used for patients with Ulcerative colitis (UC).
METHODS: Electronic databases, including PubMed and Embase, were searched from inception to identify relevant articles using search terms related to UC and psychometric analysis. This abstract reports pilot findings based on completed full-text screening to date, with ongoing data extraction. Data on study characteristics, instrument type, domains, and psychometric outcomes were extracted.
RESULTS: Based on a pilot full-text screening, 13 studies were included, consisting of 307 patients with UC. A total of 10 unique HRQOL instruments were identified; the most commonly used were the Inflammatory Bowel Disease Questionnaire (IBDQ), the short Inflammatory Bowel Disease Questionnaire, the Patient-reported outcomes measurement information system, and the SF-36. Internal consistency was reported widely, whereas fewer studies evaluated construct validity and reliability. Anxiety and depression were as high as 66% and 59%. Pediatric HRQOL was assessed using IMPACT-III and the Pediatric Quality of Life Inventory, while Instruments such as the Work Productivity and Activity Impairment Questionnaire and the UC-Work disability questionnaire were used in adult populations to measure work-related and functional outcomes.
CONCLUSIONS: Preliminary results suggest substantial heterogeneity in the HRQOL instruments used in UC, with variation in content and psychometric quality. Disease-specific tools such as the IBDQ were widely used, with generic instruments also contributing. Ongoing analysis will further characterise these measures; however, prospective research should emphasize the development of consistent, validated UC-specific HRQOL instruments that incorporate psychometric properties and support equal interpretation for clinical decision-making.