FACTORS INFLUENCING THE HEALTH-RELATED QUALITY OF LIFE AMONG PERINATAL WOMEN WITH OPIOID USE DISORDER
Author(s)
Ruth Jeminiwa, PhD1, Grace Sawicki, PharmD candidate1, Jothsana Jaimon, PharmD candidate2;
1Thomas Jefferson University, Jefferson College of Pharmacy, Philadelphia, PA, USA, 2Drake University, Des Moines, IA, USA
1Thomas Jefferson University, Jefferson College of Pharmacy, Philadelphia, PA, USA, 2Drake University, Des Moines, IA, USA
Presentation Documents
OBJECTIVES: Factors influencing health-related quality of life (HRQoL) among pregnant, postpartum, and recently miscarried women with opioid use disorder (PPMWOUD) are poorly understood. This study sought to (1) describe the proportion of participants reporting problems in each dimension of the EQ-5D-5L instrument and (2) identify the role of addiction severity and social determinants of health (SDoH) in predicting problems across these dimensions.
METHODS: We conducted a cross-sectional study of 198 PPMWOUD in a large healthcare system. A composite SDoH score was computed to sum the five barriers: lack of housing, transportation, emotional support, employment, and stigma. Addiction severity score was calculated by summing binary responses to DSM-5 diagnostic questions. Responses to EQ-5D-5L questionnaire were dichotomized into (“no problem” vs “problems”). Descriptive statistics summarized self-reported problems for each dimension of the EQ-5D-5L tool. Logistic regressions were fitted for each dimension to assess if a combination of SDoH score, addiction severity, and demographic variables predicted self-reported problems.
RESULTS: Proportion of self-reported problems includes mobility (26.8%), self-care (18.7%), usual activities (40.9%), pain/discomfort (69.7%), and anxiety/depression (84.8%). Logistic regressions results indicates that SDoH was associated with mobility (OR = 1.73, 95% CI=1.29 - 2.31, p<0.001), self-care (OR = 1.76, 95% CI=1.26 - 2.45, p<0.001), usual activities (OR = 1.32, 95% CI=1.03 - 1.68, p=0.026), and pain/discomfort(OR = 1.47, 95% CI=1.12 - 1.93, p=0.006). Addiction severity was associated with anxiety/depression (OR = 1.39, 95% CI=1.18 - 1.64, p < 0.001) while race was associated with ability to perform usual activities (OR = 0.48, 95% CI=0.24 - 0.98, p = 0.045).
CONCLUSIONS: Pain/discomfort and anxiety/depression were the most reported problems. SDoH barriers are a consistent predictor of physical and functional problems, while addiction severity primarily drives the mental health burden of this patient population. Future interventions addressing SDoH and addiction severity may improve the HRQoL of this patient population.
METHODS: We conducted a cross-sectional study of 198 PPMWOUD in a large healthcare system. A composite SDoH score was computed to sum the five barriers: lack of housing, transportation, emotional support, employment, and stigma. Addiction severity score was calculated by summing binary responses to DSM-5 diagnostic questions. Responses to EQ-5D-5L questionnaire were dichotomized into (“no problem” vs “problems”). Descriptive statistics summarized self-reported problems for each dimension of the EQ-5D-5L tool. Logistic regressions were fitted for each dimension to assess if a combination of SDoH score, addiction severity, and demographic variables predicted self-reported problems.
RESULTS: Proportion of self-reported problems includes mobility (26.8%), self-care (18.7%), usual activities (40.9%), pain/discomfort (69.7%), and anxiety/depression (84.8%). Logistic regressions results indicates that SDoH was associated with mobility (OR = 1.73, 95% CI=1.29 - 2.31, p<0.001), self-care (OR = 1.76, 95% CI=1.26 - 2.45, p<0.001), usual activities (OR = 1.32, 95% CI=1.03 - 1.68, p=0.026), and pain/discomfort(OR = 1.47, 95% CI=1.12 - 1.93, p=0.006). Addiction severity was associated with anxiety/depression (OR = 1.39, 95% CI=1.18 - 1.64, p < 0.001) while race was associated with ability to perform usual activities (OR = 0.48, 95% CI=0.24 - 0.98, p = 0.045).
CONCLUSIONS: Pain/discomfort and anxiety/depression were the most reported problems. SDoH barriers are a consistent predictor of physical and functional problems, while addiction severity primarily drives the mental health burden of this patient population. Future interventions addressing SDoH and addiction severity may improve the HRQoL of this patient population.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
CO57
Topic
Clinical Outcomes