EXPLORING LIFE SATISFACTION AS AN OUTCOME OF INTEREST FOR VALUE ASSESSMENT
Author(s)
Pearl Craig, PharmD1, A Simon Pickard, PhD1, Tessa Peasgood, PhD2, Ole Marten, PhD3, Zhihao Yang, PhD4, Maja Kuharic, PhD5;
1University of Illinois Chicago, Department of Pharmacy Systems, Outcomes and Policy, Chicago, IL, USA, 2University of Sheffield, Sheffield, United Kingdom, 3School of Public Health, Bielefeld University, Bielefeld, Germany, 4Guizhou Medical University, Guiyang, China, 5Northwestern University Feinberg School of Medicine, Chicago, IL, USA
1University of Illinois Chicago, Department of Pharmacy Systems, Outcomes and Policy, Chicago, IL, USA, 2University of Sheffield, Sheffield, United Kingdom, 3School of Public Health, Bielefeld University, Bielefeld, Germany, 4Guizhou Medical University, Guiyang, China, 5Northwestern University Feinberg School of Medicine, Chicago, IL, USA
OBJECTIVES: Life satisfaction is a key aspect of subjective well-being influenced by many factors, including physical health, social relationships, and attitude towards life. Stakeholders are increasingly exploring broader aspects of health and well-being in value propositions for new healthcare technologies. This study examined the extent to which health and non-health factors explain life satisfaction and explored similarities across key pharmaceutical markets.
METHODS: A secondary analysis of an online cross-sectional self-reported health survey was conducted in the USA, UK, and Germany from September-October 2025. The primary outcome was life satisfaction (1=Very Dissatisfied, 5=Very Satisfied). Predictor variables included socioeconomic demographics, household and healthcare affordability, chronic conditions, health status, health literacy, relationship satisfaction, caregiver status, and social support. Multivariable ordinal logistic regressions estimated adjusted associations. Odds ratios (OR) > 1 represented higher odds of better life satisfaction.
RESULTS: The analysis included 943 participants from the USA (n=347), UK (n=311), and Germany (n=285), with mean [SD] age of 45.4 [16.3], 50.3% female. Overall, 66% of participants reported being satisfied/very satisfied with life. Relationship satisfaction was strongly associated with life satisfaction (OR=4.23, 95%CI 3.57-5.0). General health (OR=1.62, 95%CI 1.37-1.9) and difficulty meeting household expenses (OR=1.43, 95%CI 1.22-1.68) were also significant. Healthcare affordability, health literacy, chronic conditions, caregiver status, social support, and gender were not significant after adjustment. Older adults (55+) reported better life satisfaction than younger adults (18-34) (OR=1.63, 95%CI 1.09-2.43). Life satisfaction was higher among respondents in Germany than the USA (OR=1.70, 95%CI 1.22-2.36), and lower among students than employed respondents (OR=0.40, 95%CI 0.21-0.77). Interaction analyses revealed similar relationship satisfaction associations across countries, while general health and household affordability had weaker associations in Germany.
CONCLUSIONS: Life satisfaction was strongly associated with relationship satisfaction across countries. Results suggest that if life satisfaction is an outcome of interest, technologies that improve social functioning warrant further investigation.
METHODS: A secondary analysis of an online cross-sectional self-reported health survey was conducted in the USA, UK, and Germany from September-October 2025. The primary outcome was life satisfaction (1=Very Dissatisfied, 5=Very Satisfied). Predictor variables included socioeconomic demographics, household and healthcare affordability, chronic conditions, health status, health literacy, relationship satisfaction, caregiver status, and social support. Multivariable ordinal logistic regressions estimated adjusted associations. Odds ratios (OR) > 1 represented higher odds of better life satisfaction.
RESULTS: The analysis included 943 participants from the USA (n=347), UK (n=311), and Germany (n=285), with mean [SD] age of 45.4 [16.3], 50.3% female. Overall, 66% of participants reported being satisfied/very satisfied with life. Relationship satisfaction was strongly associated with life satisfaction (OR=4.23, 95%CI 3.57-5.0). General health (OR=1.62, 95%CI 1.37-1.9) and difficulty meeting household expenses (OR=1.43, 95%CI 1.22-1.68) were also significant. Healthcare affordability, health literacy, chronic conditions, caregiver status, social support, and gender were not significant after adjustment. Older adults (55+) reported better life satisfaction than younger adults (18-34) (OR=1.63, 95%CI 1.09-2.43). Life satisfaction was higher among respondents in Germany than the USA (OR=1.70, 95%CI 1.22-2.36), and lower among students than employed respondents (OR=0.40, 95%CI 0.21-0.77). Interaction analyses revealed similar relationship satisfaction associations across countries, while general health and household affordability had weaker associations in Germany.
CONCLUSIONS: Life satisfaction was strongly associated with relationship satisfaction across countries. Results suggest that if life satisfaction is an outcome of interest, technologies that improve social functioning warrant further investigation.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
PCR77
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
No Additional Disease & Conditions/Specialized Treatment Areas