A STUDY ON ASSESSMENT OF RISK FACTORS, COMPLICATIONS AND CLINICAL EFFICACY OF HEPATOPROTECTIVES IN LIVER DISEASE
Author(s)
Naveen K. S, PharmD1, Ramya N, PharmD2;
1Rajiv Gandhi University of Health Sciences, Assistant Professor, Chitradurga, India, 2Nitte deemed to be university, Bangalore, India
1Rajiv Gandhi University of Health Sciences, Assistant Professor, Chitradurga, India, 2Nitte deemed to be university, Bangalore, India
OBJECTIVES: This study assessed risk factors, severity by using Child-Pugh classification, complications, diagnostic patterns and the effectiveness of hepatoprotective agents in liver disease patients.
METHODS: A prospective observational study was conducted over a period of six months at Basaveshwara Medical College Hospital and Research Centre, Chitradurga, enrolling 120 patients diagnosed with liver disease. Demographic and clinical data were collected including treatment regimens using hepatoprotective agents. Changes in biochemical markers (SGOT, SGPT, Bilirubin) pre and post treatment were analyzed using Student’s t-test. The data were analysed using IBM Statistical Package for the social science version 20.
RESULTS: among 120 participants, 77% were Male and the highest incidence occurred in males aged 38-57 years. Alcohol consumption (72%) followed by smoking (22%) are major risk factor. Impaired synthetic function (63%) followed by portal hypertension (53%) are the most common complication. Hepatoprotective agents are Thiamine followed by Vitamin-K and Ursodeoxycholic acid were commonly prescribed. A statistically Significant reduction was observed in the post-treatment including SGOT (40%), SGPT (38%) and total bilirubin (39%) (p<0.001).
CONCLUSIONS: Hepatoprotective agents, especially thiamine, vitamin k was shown improvement in liver function. Pre identification of risk-factor and timely therapeutic intervention can improve clinical outcomes in the liver disease.
METHODS: A prospective observational study was conducted over a period of six months at Basaveshwara Medical College Hospital and Research Centre, Chitradurga, enrolling 120 patients diagnosed with liver disease. Demographic and clinical data were collected including treatment regimens using hepatoprotective agents. Changes in biochemical markers (SGOT, SGPT, Bilirubin) pre and post treatment were analyzed using Student’s t-test. The data were analysed using IBM Statistical Package for the social science version 20.
RESULTS: among 120 participants, 77% were Male and the highest incidence occurred in males aged 38-57 years. Alcohol consumption (72%) followed by smoking (22%) are major risk factor. Impaired synthetic function (63%) followed by portal hypertension (53%) are the most common complication. Hepatoprotective agents are Thiamine followed by Vitamin-K and Ursodeoxycholic acid were commonly prescribed. A statistically Significant reduction was observed in the post-treatment including SGOT (40%), SGPT (38%) and total bilirubin (39%) (p<0.001).
CONCLUSIONS: Hepatoprotective agents, especially thiamine, vitamin k was shown improvement in liver function. Pre identification of risk-factor and timely therapeutic intervention can improve clinical outcomes in the liver disease.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
CO54
Topic
Clinical Outcomes
Topic Subcategory
Clinical Outcomes Assessment
Disease
SDC: Diabetes/Endocrine/Metabolic Disorders (including obesity), SDC: Gastrointestinal Disorders