TRENDS IN MORTALITY RELATED TO CIRRHOSIS IN COLOMBIA 2000 - 2024
Author(s)
Betty Morales Arrieta, MD. Hepatóloga1, Ismael De Jesús Yepes Barreto, MD. Gastroenterólogo-Hepatólogo1, Nelson R. Alvis Zakzuk, Jr., MBA2, Nelson Alvis-Guzman, MPH, PhD, MD3;
1UNIVERSIDAD DE CARTAGENA, Cartagena, Colombia, 2ALZAK Foundation, Cartagena, Colombia, 3Universidad de la Costa, Professor, Barranquilla, Colombia
1UNIVERSIDAD DE CARTAGENA, Cartagena, Colombia, 2ALZAK Foundation, Cartagena, Colombia, 3Universidad de la Costa, Professor, Barranquilla, Colombia
OBJECTIVES: To describe mortality trends related to Cirrhosis in Colombia 2000-2024
METHODS: This was a descriptive study using vital registration. ICD-10 codes related to cirrhosis (K74.6, K70.3, K74.5, K74.3, K71.7, K74.0, K74.4, K74.2, K74.1) were used. The distribution of causes by age, sex, and year was estimated. Proportional mortality rates (per 100,000) were estimated during the study period. Trends in cirrhosis-related mortality (CiMR) were analysed using Joinpoint regression (JPR) to determine inflection points for temporal analysis and annual percent change (APC). Data were obtained from the national population statistics agency, DANE.
RESULTS: Between 2000 and 2024, there were 55,077 deaths (1.0% of the total) related to cirrhosis. This was 62.1% in men and 69.3% in people aged over 59 (64.5% in men and 77.2% in women). The mean age at death was 66.1 years (SD: 14.2) (65.8 years (SD: 14.3) in women and 64.6 years (SD: 14.0) in men). 98.0% of deaths were from K74.6 (other and unspecified cirrhosis of the liver) and K70.3 (alcoholic cirrhosis of the liver), of which 75.7% were from K74.6 and 22.3% from K70.3. Between 2000 and 2024, the cirrhosis-specific mortality rate (CiMR) increased from 4.38 (95% CI: 4.18-4.59) to 5.44 (95% CI: 5.24-5.64). In men, it increased from 5.95 (95% CI: 5.60-6.29) to 6.62 (95% CI: 6.30-6.93); in women, it increased from 2.88 (95% CI: 2.64-3.11) to 4.31 (95% CI: 4.06-4.56). The APC of the CiMR was 1.1734 (0.8042-1.5431); in men, it was 0.7370 (0.3053-1.1745), and in women it was 1.9108 (1.4968-2.3295). All increases were significant. The men-to-women rate ratio decreased from 2.07 (2.12-2.02) to 1.54 (1.55-1.52) over the period.
CONCLUSIONS: The mortality rate related to cirrhosis increased significantly in Colombia during the period when the gap between men and women narrowed.
METHODS: This was a descriptive study using vital registration. ICD-10 codes related to cirrhosis (K74.6, K70.3, K74.5, K74.3, K71.7, K74.0, K74.4, K74.2, K74.1) were used. The distribution of causes by age, sex, and year was estimated. Proportional mortality rates (per 100,000) were estimated during the study period. Trends in cirrhosis-related mortality (CiMR) were analysed using Joinpoint regression (JPR) to determine inflection points for temporal analysis and annual percent change (APC). Data were obtained from the national population statistics agency, DANE.
RESULTS: Between 2000 and 2024, there were 55,077 deaths (1.0% of the total) related to cirrhosis. This was 62.1% in men and 69.3% in people aged over 59 (64.5% in men and 77.2% in women). The mean age at death was 66.1 years (SD: 14.2) (65.8 years (SD: 14.3) in women and 64.6 years (SD: 14.0) in men). 98.0% of deaths were from K74.6 (other and unspecified cirrhosis of the liver) and K70.3 (alcoholic cirrhosis of the liver), of which 75.7% were from K74.6 and 22.3% from K70.3. Between 2000 and 2024, the cirrhosis-specific mortality rate (CiMR) increased from 4.38 (95% CI: 4.18-4.59) to 5.44 (95% CI: 5.24-5.64). In men, it increased from 5.95 (95% CI: 5.60-6.29) to 6.62 (95% CI: 6.30-6.93); in women, it increased from 2.88 (95% CI: 2.64-3.11) to 4.31 (95% CI: 4.06-4.56). The APC of the CiMR was 1.1734 (0.8042-1.5431); in men, it was 0.7370 (0.3053-1.1745), and in women it was 1.9108 (1.4968-2.3295). All increases were significant. The men-to-women rate ratio decreased from 2.07 (2.12-2.02) to 1.54 (1.55-1.52) over the period.
CONCLUSIONS: The mortality rate related to cirrhosis increased significantly in Colombia during the period when the gap between men and women narrowed.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
EPH11
Topic
Epidemiology & Public Health
Disease
SDC: Gastrointestinal Disorders