GASTROINTESTINAL TOLERANCE, MALNUTRITION, AND HEALTHCARE RESOURCE UTILIZATION ARE IMPACTED IN PEDIATRIC AND ADULT OUTPATIENTS USING A PEA PEPTIDE ENTERAL FORMULA
Author(s)
Vanessa Millovich, DCN, MS, RD, CNSC, Irene Olsen Shingara, PhD, RD, LDN, Christina J. Valentine, MD, RDN, FAAP, FASPEN;
Kate Farms, Medical Sciences, Goleta, CA, USA
Kate Farms, Medical Sciences, Goleta, CA, USA
OBJECTIVES: Research on pea protein plant-based formulas (PPPBF) have demonstrated gastrointestinal (GI) tolerance and prebiotic changes which could help to minimize healthcare costs associated with malnutrition. This study aimed to gather retrospective data from a claims database on outpatients who were prescribed (“index date”) a hydrolyzed protein formula (or “peptide formula”) made with pea protein (Pea-Peptide group; PPG) or dairy protein (Dairy-Peptide group; DPG).
METHODS: Data on demographics, clinical characteristics, and healthcare resource utilization (HCRU) were collected (June 1st, 2020 to September 30th, 2023). Unadjusted descriptive analyses compared data from 180 days before (pre-index) and 90 days after (post-index) index date. Clinical characteristics included GI symptoms of intolerance, malnutrition, weight loss, and mortality risk (Charlson co-morbidity index; CCI). To better understand HCRU post-index, GI medication utilization, 90-day all-cause hospital readmission and all-cause outpatient visits were collected.
RESULTS: Compared to the DPG (n=1,120), the PPG (n=291) was older on average (20.9 vs. 18.4 years), had a higher proportion of children aged 1-3 (8.6% vs. 3.5%), and had a higher percentage of patients with a CCI score of >1. Pre-index, the PPG had a higher baseline incidence of "any GI intolerance symptom" (18.9% vs. 16.2%), malnutrition (7.2% vs. 4.6%) and constipation (10.7% vs. 8.4%). During the 90-day post-index period, the PPG showed a greater decrease in the rate of malnutrition (37.5% vs. 4.3%). Rates of all-cause hospital readmissions at 1-30 days (3.1% vs. 3.5%) and 31-90 days (3.1% vs. 3.9%) post-index were also slightly lower in the PPG.
CONCLUSIONS: GI symptoms of intolerance, rates of malnutrition, and all-cause readmissions are all factors contributing to HCRU. The improvements in these factors seen in the pea-peptide group may result in lower HCRU compared to the dairy-peptide group. Larger, randomized studies adjusted for potential confounders and stratified by age group are needed.
METHODS: Data on demographics, clinical characteristics, and healthcare resource utilization (HCRU) were collected (June 1st, 2020 to September 30th, 2023). Unadjusted descriptive analyses compared data from 180 days before (pre-index) and 90 days after (post-index) index date. Clinical characteristics included GI symptoms of intolerance, malnutrition, weight loss, and mortality risk (Charlson co-morbidity index; CCI). To better understand HCRU post-index, GI medication utilization, 90-day all-cause hospital readmission and all-cause outpatient visits were collected.
RESULTS: Compared to the DPG (n=1,120), the PPG (n=291) was older on average (20.9 vs. 18.4 years), had a higher proportion of children aged 1-3 (8.6% vs. 3.5%), and had a higher percentage of patients with a CCI score of >1. Pre-index, the PPG had a higher baseline incidence of "any GI intolerance symptom" (18.9% vs. 16.2%), malnutrition (7.2% vs. 4.6%) and constipation (10.7% vs. 8.4%). During the 90-day post-index period, the PPG showed a greater decrease in the rate of malnutrition (37.5% vs. 4.3%). Rates of all-cause hospital readmissions at 1-30 days (3.1% vs. 3.5%) and 31-90 days (3.1% vs. 3.9%) post-index were also slightly lower in the PPG.
CONCLUSIONS: GI symptoms of intolerance, rates of malnutrition, and all-cause readmissions are all factors contributing to HCRU. The improvements in these factors seen in the pea-peptide group may result in lower HCRU compared to the dairy-peptide group. Larger, randomized studies adjusted for potential confounders and stratified by age group are needed.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
RWD13
Topic
Real World Data & Information Systems
Disease
SDC: Gastrointestinal Disorders, SDC: Pediatrics, STA: Multiple/Other Specialized Treatments, STA: Nutrition