REGENERATIVE MEDICINE IN CHRONIC AND COMPLEX WOUNDS. PRELIMINARY ANALYSIS OF ECONOMIC IMPACT REVIEW DATA FROM HEOR IN A PRIVATE HEALTH SYSTEM IN BRAZIL/ LATAM/ LMIC .
Author(s)
ELIO TANAKA, MD1, Vivian Chien, MD2, Isabela Farinhaki, MD3, Helena Maria Romcy, MSc, MD4, Sergio Machado, MD5, GIOVANNA SCARLATTE MARCONDES, RN6, Gabriel Kenzo Tanaka, MD6.
1MEDICAL AUDIT, TNK MEDICAL AUDIT INSTITUTION, CURITIBA, Brazil, 2TNK MEDICAL AUDIT INSTITUTION, Sao Paulo, Brazil, 3TNK MEDICAL AUDIT INSTITUTION, CURITIBA, Brazil, 4ABEA, Fortaleza, Brazil, 5RESEARCH, UDELAR / UNIVERSIDADE DE LA REPUBLICA , MONTEVIDEO , URUGUAI, MONTEVIDEO, URUGUAY, Uruguay, 6RESEARCH, TNK MEDICAL AUDIT INSTITUTION, SÃO PAULO, Brazil.
1MEDICAL AUDIT, TNK MEDICAL AUDIT INSTITUTION, CURITIBA, Brazil, 2TNK MEDICAL AUDIT INSTITUTION, Sao Paulo, Brazil, 3TNK MEDICAL AUDIT INSTITUTION, CURITIBA, Brazil, 4ABEA, Fortaleza, Brazil, 5RESEARCH, UDELAR / UNIVERSIDADE DE LA REPUBLICA , MONTEVIDEO , URUGUAI, MONTEVIDEO, URUGUAY, Uruguay, 6RESEARCH, TNK MEDICAL AUDIT INSTITUTION, SÃO PAULO, Brazil.
OBJECTIVES: Chronic and complex wounds impose substantial clinical and economic burdens on health systems, particularly in low- and middle-income countries (LMICs) where resources are limited. We study the bridge between early scientific findings and robust evidence-generating initiatives ready for decision-making.
METHODS: Preliminary data from private healthcare systems in Brazil regarding Regenerative Medicine Interventions was collected . HEOR implications RWD & RWE was analysis , as direct cost impact , indirect cost savings, budget impact considerations for private health plans and cross-country considerations in LMIC/LATAM contexts .
RESULTS: Preliminary data from private healthcare systems in Brazil suggest autologous regenerative therapies, as platelet-rich plasma (PRP) therapy and adipose-derived stem cell (ADSC) or autologous fat grafting, can facilitate healing in otherwise non-healing complex wounds. Key findings include: significant wound area reduction (>80% in 64% of patients), complete healing in approximately 48% of cases with a mean healing time of ~49 days, safe utilization without major adverse events, primarily applied as adjuncts to surgical debridement and standardized wound care, with some patients receiving split-thickness skin grafts . Incorporation of regenerative medicine interventions into HEOR frameworks supports their potential value-based adoption to reduce chronic wound-related costs and improve patient outcomes, aligning with sustainability goals for LMIC healthcare systems.
CONCLUSIONS: Economic aspects such as higher initial costs can be offset by lasting functional benefits, reduced need for surgeries, and lower use of healthcare services; local cost-effectiveness modeling is recommended. Integration of RWE/RWD is crucial, as registries and pragmatic studies are essential to validate the efficacy and cost-effectiveness of RWE in LATAM RWD and low-income populations. Further research is needed to fully understand the molecular and genetic mechanisms involved, as well as to expand HEOR analysis.
METHODS: Preliminary data from private healthcare systems in Brazil regarding Regenerative Medicine Interventions was collected . HEOR implications RWD & RWE was analysis , as direct cost impact , indirect cost savings, budget impact considerations for private health plans and cross-country considerations in LMIC/LATAM contexts .
RESULTS: Preliminary data from private healthcare systems in Brazil suggest autologous regenerative therapies, as platelet-rich plasma (PRP) therapy and adipose-derived stem cell (ADSC) or autologous fat grafting, can facilitate healing in otherwise non-healing complex wounds. Key findings include: significant wound area reduction (>80% in 64% of patients), complete healing in approximately 48% of cases with a mean healing time of ~49 days, safe utilization without major adverse events, primarily applied as adjuncts to surgical debridement and standardized wound care, with some patients receiving split-thickness skin grafts . Incorporation of regenerative medicine interventions into HEOR frameworks supports their potential value-based adoption to reduce chronic wound-related costs and improve patient outcomes, aligning with sustainability goals for LMIC healthcare systems.
CONCLUSIONS: Economic aspects such as higher initial costs can be offset by lasting functional benefits, reduced need for surgeries, and lower use of healthcare services; local cost-effectiveness modeling is recommended. Integration of RWE/RWD is crucial, as registries and pragmatic studies are essential to validate the efficacy and cost-effectiveness of RWE in LATAM RWD and low-income populations. Further research is needed to fully understand the molecular and genetic mechanisms involved, as well as to expand HEOR analysis.
Conference/Value in Health Info
2026-09, ISPOR Asia Pacific 2026, Bangkok, Thailand
Value in Health, Volume 55, Issue S1
Code
RWD13
Topic
Real World Data & Information Systems
Topic Subcategory
Data Protection, Integrity, & Quality Assurance, Distributed Data & Research Networks, Health & Insurance Records Systems, Reproducibility & Replicability
Disease
SDC: Diabetes/Endocrine/Metabolic Disorders (including obesity), SDC: Sensory System Disorders (Ear, Eye, Dental, Skin), STA: Genetic, Regenerative & Curative Therapies, STA: Multiple/Other Specialized Treatments