OBJECTIVES: To evaluate the performance and efficacy of a custom-designed system utilizing GPT-4o and Retrieval-Augmented Generation (RAG) for extracting specific fields from scientific journal articles, compared to the gold standard of domain expert extraction.

METHODS: We developed a custom system leveraging OpenAI's GPT-4o model and Assistant API, enhanced with RAG capabilities. The evaluation process compared machine extraction with domain expert extraction across 36 diverse studies, focusing on consistency and completeness of data field identification. Key fields evaluated included study design, country, setting, sample size, RCT phase, and blinding, encompassing various extraction complexities.

RESULTS: The system extracted 168 data fields across the studies. Of these, 141 fields aligned precisely with domain expert extractions, yielding a consistency rate of 84% (141/168) between expert and machine. Performance varied across field types, with the highest similarity to expert extraction observed for straightforward fields like country and sample size. More nuanced and complex fields, particularly study design, presented greater challenges, showing the lowest similarity to expert extractions.

CONCLUSIONS: The GPT-4o and RAG-based system demonstrates significant potential for enhancing efficiency and accuracy in scientific data extraction. While the 84% match with the gold standard is promising, it also highlights areas for improvement. Further refinement and rigorous validation are necessary to elevate performance across all data field categories, especially for complex fields like study design.