Session (CTI)

ISSUEArtificial intelligence (AI) is rapidly transforming HEOR and HTA workflows, with increasing interest in moving from simple prompting and workflow automation toward more autonomous agentic AI systems. While AI offers significant opportunities to enhance productivity and augment expertise, its increasing autonomy also raises important questions around accountability, transparency, trust, and scientific rigour. As AI capabilities continue to advance, how should the HEOR and HTA community navigate increasing levels of AI autonomy while ensuring that human judgement and accountability remain central to decision-making? What guardrails that should be in place?This panel will explore how organisations can responsibly navigate increasing AI autonomy, examining when greater autonomy adds value and the governance and validation needed to maintain trust, confidence, and human judgement in decision-making.

OVERVIEWThe moderator, Bill Malcolm, will introduce the topic and frame the discussion on responsibly navigating increasing AI autonomy in HEOR and HTA. (6 min)Dalia Dawoud will provide the HTA and policy perspective (13 min), discussing the role of human oversight, transparency, and governance in AI-enabled workflows and the implications for evidence generation and decision-making.Jaime Caro will provide a methodological and research perspective (13 min), exploring how increasing AI autonomy may reshape professional practice, where additional complexity adds value versus unnecessary risk, and what should remain uniquely human in decision-making.Siguroli Teitsson will draw on practical industry experience (13 min) discussing how organisations assess and deploy different levels of AI autonomy, and how workflow design, governance and human judgement remain critical to successful adoption.The session will conclude with a moderated panel discussion and audience Q&A (15 min) exploring practical approaches to navigating increasing AI autonomy while maintaining human judgement, accountability, and trust across the HEOR and HTA ecosystem. To encourage active participation, the session will incorporate live audience polling and voting on key questions.