Session (CTI)

Health economic models are widely used to inform healthcare reimbursement decisions and pricing negotiations, but in practice there is no consistent approach to validating them or reporting how validation has been conducted. While existing ISPOR-SMDM guidance highlights the importance of validation, so far this has not been consistently applied in research or economic evaluation of health technology. This session will be delivered as an interactive panel discussion. After a short introduction by Dr. Salah Ghabri, task force members will present the joint task force’s draft recommendations. These recommendations build on recent advances in modelling, software development, real-world evidence, and the growing use of artificial intelligence (AI). The task force’s aim is to provide practical and flexible guidance that can be applied across different model types, decision settings, and stakeholder groups. Dr. Beate Jahn will discuss draft recommendations and practical challenges covering key aspects of model validation, including conceptual model validation, input data validation, model verification and validation of model outcomes. Dr. Isaac Corro Ramos will present draft recommendations for terminology, available tools, and validation planning, documentation and reporting. Finally, Dr. Mafalda Ramos will provide a stakeholder analysis, discussing the extent to which these draft recommendations can be applied in practice, and what could be the role/responsibility of various stakeholders, including HTA agencies, industry, CROs, journal editors and academic researchers. Lastly, the audience will then be invited to provide feedback to help shape the final recommendations before publication, ask questions, and share their experiences.