Session (CTI)

PURPOSE: This workshop will provide guidance from the ISPOR Good Practice Task Force for accounting for preference heterogeneity in stated choice data to support researchers and decision makers in moving beyond averages in data analysis, reporting, and results interpretation. DESCRIPTION: Stated choice data is increasingly considered in regulatory, HTA, policy, and clinical decisions. While best-practice guidance for generating, analyzing and applying stated choice data exists, clear recommendations concerned with preference heterogeneity remain limited. This is in stark contrast to the importance of the topic. Accounting for differences in healthcare preferences between individuals is decision-relevant and avoids bias. Practical guidance can also reduce the perceived complexity of various analytical methods. Using an interactive benefit-risk case study, the workshop will highlight the relevance of the topic, outline considerations during data analysis, and make recommendations for results interpretation. The workshop will be moderated by Deborah Marshall (10 minutes). Francesco Pignatti will introduce the case study, that considers the regulatory approval of a health technology with benefits, uncertainty, treatment burden, and adverse event risks. He will specifically reflect on how preference heterogeneity can inform regulatory decision making (10 minutes). The remaining speakers will draw on the case study when presenting key elements of the ISPOR Good Practice Task Force. Sebastian Heidenreich will discuss key methodological considerations for data analysis (10 minutes). Axel Mühlbacher will deliver guidance on results presentation and interpretation (10 minutes). The workshop will conclude with practical recommendations for communicating heterogeneity to regulators, HTA bodies, payers, clinicians, and patient organizations (5 minutes). Participants will actively take part by judging whether technology in the case study is acceptable for the full population, subgroups, or not acceptable. Live polling will be conducted before and after the discussion from a regulatory perspective. The workshop will end with questions and answers.