OBJECTIVES: To explore patient reported outcomes (PROs) of patients with Metastatic Melanoma. METHODS: A systematic review of literature was performed in Pubmed and Embase in order to find patient reported outcomes of patients with metastatic melanoma. RESULTS: During pre-diagnostic stage, tiredness, pain, itchy moles, fever and gastrointestinal pain was reported. During the advanced stage, insomnia, pain, physical impairment, functional loss of an arm or leg was reported as a consequence of brain metastasis. Fatigue, anxiety, depression, work absenteeism, need of informal care, and impairment of social activities were the most frequent PROs reported from patients with metastatic melanoma. CONCLUSIONS: The exploration of additional dimensions of patients’ consequences in metastatic melanoma delivers a broader overview of what else matters to patients and should be taken into account by decision bodies and clinicians alongside survival and progression of disease.