OBJECTIVES: To compare the impact of 11 types of cancer on different domains of HRQL using the FACT-G and EQ-VAS. METHODS: Patients diagnosed with advanced cancer of the bladder, brain, breast, colorectal, head/neck, hepatobiliary/pancreas, kidney, lung, lymphoma, ovary or prostate completed HRQL assessments. HRQL was compared between patient groups for each subscale of the FACT-G, i.e., physical well-being (PWB), social/family wellbeing (SWB), emotional well-being (EWB) and functional well-being (FWB), and EQ-VAS, unadjusted and adjusted for age/gender using regression models. RESULTS: Approximately 50 patients were recruited for each cancer group (total n=534). Mean age (SD) ranged from 52(11) (brain) to 70(8) (prostate). Unadjusted mean (SD) scores for PWB ranged from 66.8(17.2) (head/neck) to 78.1(21.3) (prostate); for SWB ranged from 81.4(19.1) (brain) to 90.6(22.0) (kidney); for EWB ranged from 61.7(16.0) (breast) to 72.0(16.9) (prostate); and FWB ranged from 54.7(20.2) (head/neck) to 67.8(18.5) (prostate). EQ-5D VAS mean scores were lowest for head/neck [61.8(21.7)] and highest for colorectal [72.0(17.1)]. Compared to lymphoma, adjusting for age/gender, PWB mean scores (SE) were significantly lower for patients with head/neck [-10.9(4.0)], hepatobiliary [-10.9(4.0)], and kidney [-9.7(4.0)]. FWB mean scores were significantly lower for head/neck [-10(3.2)], hepatobiliary [-8.9(3.1)], bladder [-7.7(3.6)], and lung [-6.7(3.1)]. Patients 65 years and older had mean (SE) scores for PWB=+9.2(2.1), EWB=+2.9(1.0), FWB=+3.1(1.6), and EQ VAS=+4.5(2.1) compared to patients aged 45 to 64. For median rank across all FACT subscales, hepatobiliary ranked worst and prostate the highest. Adjusting for age and gender, hepatobiliary ranked worst and lymphoma highest based on FACT median scores, while breast ranked lowest and colorectal highest based on mean VAS scores. CONCLUSION: Older cancer patients generally report greater well-being across all domains, but age-adjusted results suggest hepatobiliary and head/neck cancer have significantly worse HRQL among different types of cancer, particularly in terms of PWB and FWB.