HPV is currently the most common sexually transmitted disease in the United States. It is highly prevalent among sexually active men and women, affecting 20 million people with 5.5 million new cases occurring yearly. About 75% of sexually active individuals will acquire the infection at some point during their lifetime. The highest rates of genital HPV infection have consistently been found in sexually active college age population (20-24-age bracket). OBJECTIVES: To assess knowledge of HPV among students attending an HBCU and to test the effectiveness of an educational intervention program. METHOD: The participants for this research project were 3rd year Pharm.D college students enrolled at a HBCU in Florida. The design was repeated measures with an intervention versus control group. A general knowledge HPV survey was administered to assess HPV knowledge. T-tests were used to analyze the data. RESULTS: Eighty-six percent of the population had heard of HPV. Knowledge of HPV was generally low; out of 6 questions posed only 2 were answered correctly by more than 70% of the population. Education was effective in increasing knowledge of HPV [t(50)=4.53, p=.000]. CONCLUSIONS: Awareness of HPV in this population was high but knowledge was low. Simple educational material is effective in increasing knowledge of HPV.