OBJECTIVES: Is to analyze trends in prescription habits and rational usage of cardiovascular medicines (CM) in Belgrade population, as well as expenditure data regarding drug policy changes and to make evaluation in terms of the most used CM. METHODS: We used database from Public pharmacy chain - Pharmacy “Belgrade” corresponding to population of 1.57 M, with conventional data grouping and database analysis. All information on CM were based on prescriptions, which were reimbursed by national Health Insurance Fund (HIF). The calculations included: DDD methods (unit: DDD/1000 inhabitants/day) and monetary cost for years level (2005-2006). RESULTS: Expenditure of CM expressed as percentage of all used medicines during two years, shows that a third of the overall financial value was spent in this group (33.13% in 2005; 35.33% in 2006).The first three groups of CM with highest financial share (monetary cost in % of all CM) are agents acting on the renin-angiotensin system 49.72%, calcium channel blockers 24.16%, beta blocking system10.00% (2005); agents acting on the renin-angiotensin system 47.77%, calcium channel blockers 22.99%, beta blocking system11.28% (2006). The usage of CM expressed in DDD units reveals that in Belgrade population the most prescribed CM is enalapril maleate during two years (71.22 in 2005; 74.89 in 2006). The biggest increase has been shown in the usage of fosinopril sodium (from 5.44 in 2005 to 10.46 in 2006). CONCLUSION: Analysis and evaluation of the data has shown that there had been increase in expenditure of CM in these periods. The biggest increase is notified in the usage of fosinopril sodium in both financial values and DDD units, conducted by drug policy changes (reimbursement list). Monitoring of the CM usage in longer period can provide further useful information about rational use of this group of medicines.