OBJECTIVES: To investigate the feasibility, and patient/psychiatrist acceptability, of sending medication reminders and well-being questions to patients receiving quetiapine via SMS-messages. METHODS: This study was conducted by 7 Belgian psychiatrists in outpatients receiving quetiapine according to local label and considered capable of using their cellular-phone and sending SMS-messaging. Twenty-seven outpatients (11 male; 16 female, mean age: 35.3 years) were followed for 8 to12 weeks in this psychiatrist assessed, pilot-study. Patients received SMS-messages twice daily to remind them to take their medication and enquire about their well-being, fun messages could be received optionally. Patients' response was monitored by psychiatrists via a website, and subsequently used to assess technical feasibility. RESULTS: Patients responded to 77% of the SMS-messages (of which 84% total response, 13% inaccurate response, 3% late response). Twenty patients completed the study. The mean study duration was 9.4 weeks. Response was higher in patients who were supported in their disease by family/friends and who showed good motivation. More than 50% of the patients rated the degree of support offered by SMS as valuable (to a significant/reasonably extent). 71% appreciated the fun messages. The 2 major benefits expressed by the patients were the feeling of being cared for (n=11/21) and the reminding to take their medication (n=7/21). Most of the psychiatrists felt that the system helped improve compliance and relationship with the patient. Psychiatrists felt the system was valuable to 19/22 patients, 16/24 patients remained compliant with the system and 16/22 patients felt the frequency of SMS-messages was acceptable. There was a strong correlation between patients giving positive well-being responses and SMS-compliance (R Pearson=0.72, p<0.001). CONCLUSION: The technology was favorably accepted and performed well. The high levels of SMS-compliance and benefits expressed by patients and psychiatrists support a larger-scale assessment of this possibility for assistance to healthcare providers and patients.