OBJECTIVES: To issue orthogonal scores from the 52 standardized data collected by a Humphrey visual field (VF) perimetry that maximize between-variance and minimize within-variance. METHODS: 437 VF were collected and classified into 7 clinical groups: irregularities of VF (IVF), Nasal step (NaS), Arcuate scotoma (AC), Para-central scotoma (PCS), Blind spot enlargement (BSE), Diffuse deficit (DD), Advanced deficit (AD). Number and contents of scores were identified using a principal component analysis (Varimax) followed by an ascending hierarchical clustering analysis. Internal consistency was checked with Cronbach alpha. Scores were compared across the clinical groups with an Anova. RESULTS: Patients totaling 54.7% of the patients were older than 60. Mean defect was -9.21 on average and PSD was 6.50. Six scores were identified: 4 peripheral scores (Nasal Superior NS, Nasal Inferior NI, Temporal Superior TS, Temporal Inferior TI) and 2 para-central scores (superior PCSS, inferior PCSI). Cronbach alphas were always between 0.90 and 0.97. The six scores decreased simultaneously from IVF, DD to AD. AC had lower scores in NS, NI and TS. PCS had a lower PCSS. BSE had lower scores in TS and TI. NaS had lower scores in NS and NI. CONCLUSION: Six orthogonal scores were found to be optimal from the Humphrey perimetry matrix. Internal reliability was good. Ability to discriminate between clinical subgroups was found. Further analyses on longitudinal data need to be performed to confirm our findings.