Introduction:Influenza (IZ) is a highly contagious acute respiratory disease with self-limiting duration, representing serious health risks for the elderly and those with chronic diseases. Vaccination is effective, but the most vulnerable population remains at risk of IZ. New, drugs entered the market, able to reduce IZ symptoms by 1.5 °V2 days when taken within 48h of symptom onset. We investigated the WTP for these drugs under the constraint of information and prescription. METHOD: Population: Health professionals, patients with chronic diseases and young healthy adults. Willingness to pay (WTP) was asked through closed ended questions, using a payment card system with increasing and decreasing bidding ranges. Questionnaires contained 3 scenarios including 2 levels of information and were randomly allocated. 1rst scenario informed about IZ and asked WTP for no IZ risk, the 2nd WTP for the drugs, under time and office visit constraint, 3rd scenario addressed WTP for drugs if obtainable over the counter (OTC). RESULTS: We obtained 1594 answers, 59% female 41% male, evenly distributed for information, starting point and insurance. For scenario 2, 36% were unwilling to give anything, while only 22% answered nothing with the option of having the drug OTC, 41% were even willing to give more than 80Sfr. WTP decreased significantly with age. Insurance had no influence on WTP and health professionals had a significantly lower WTP than others. Bidding ranges had no influence, neither did the level of information. Participants who had been vaccinated against influenza last year were willing to give more. CONCLUSION: We completed successfully the first large randomized WTP study in Health Care. Respondents valued independent decision-making, favouring the 3rd scenario Preferences of participants were much lower than the drugs market price (CHF 80). Further large WTP studies need to be undertaken to confirm the WTP approach in Health Care.