OBJECTIVES: Assess the impact of atopic dermatitis (AD) on parent’s quality of life (QoL) and use of health direct resources in patients between 2 and 12 years old. METHODS: An observational burden-disease study of nine months of follow-up in which AD patients 2 to 12 years old were included according to Hanifin&Rajka diagnostic criteria. Four visits were conducted per protocol (baseline, 3, 6, 9 months). Disease severity was assessed by Investigator’s Global Assessment(IGA). Parents’ QoL was assessed by Parents Index of Quality of Life Atopic Dermatitis (PiQoL-AD) and by Visual Analogue Scale(VAS) of the EQ-5D questionnaire. Use of direct resources in the last three months were assessed retrospectively by medical files data or direct interviews to patients’ parents. RESULTS: Results are referred to baseline visit. A total of 240 children with AD were included in the analysis, with mean age (SD) 5.3 (2.7), 52% were boys. The most frequent careers were mothers (87.8%), 36.24 (4.9) years older (mean(SD)). 19.18% of patients had clear or almost clear AD (IGA<2), 31.25% had mild disease (IGA=2), 37.91% had moderate disease (IGA=3) and 11.68% had severe or very severe disease (IGA=4 or IGA=5). Disease severity had a significant impact on parent’s QoL: mean scores of PIQoL-AD questionnaire increased 4.9 points and VAS score decrease 16.28 points (p<0.5), indicating a worsening health state. In the last 3 months, 79.69% of patients required medical assistance, mainly from paediatricians or dermatologists; 81.84% pharmacological treatment and 24.11% laboratory tests, 17.61% unscheduled visits and 12.73% went to the Emergency Department. Use of direct resources increased with severity (p<0.5). CONCLUSIONS: Parents’ QoL tends to reduce progressively from mild AD states while resource utilization increases progressively. Proper management of AD may help maintain patients in less severe disease states, reducing the negative impact on quality of life and on resource utilization.