OBJECTIVES: The objective of our study was to describe the profile of French women suffering from Chronic venous disease (CVD). METHODS: Symptomatic women patients suffering from CVD (CEAP clinical classes C0 to C4), aged over 18, newly treated by their GP with a phlebotropic drug were enrolled in the study. They completed a self-questionnaire including the SF-12, the CES-D and the CIVIQ scales at day zero, day three and seven. RESULTS: This analysis includes the first 399 patients assessed at inclusion. Mean age was 45.0 years old (SD=11, n=370). A total of 65.7% have a professional activity, 32% practice sport, 33% are smokers, 78.4% gave birth already and 50% are under oral contraceptive. A total of 9.1% wear compression stockings. At inclusion (n=374), MCS-12 and PCS-12 were respectively 44.7 (SD=10.6) and 46.4 (SD=8.4); and the mean CIVIQ score was 32.6 (SD=1.1). Concerning the CES-D, the mean score were 14.9 (SD=10.2), the results highlighting a possible depressive symptomatology in 36.3% of our population (score 17),and a probable depressive symptomatology in 22.0% of our population (score 23). CONCLUSIONS: CVD has a great impact on women. The SF-12 mean scores were below those of the age- and gender-matched general population. Women with CVD report greater risk of high depressive symptoms, compared to the study of Rield where 23.1% of women did (CES-D score 16, age 65 to 75). The impact of CVD on patients daily life is high even if it seems relative compared to the mean scores obtained when initially validating the CIVIQ; for example for patients suffering venous insufficiency of lower limb and arteritis mean score was 53.08(SD=14.9), unfortunately comparison data with patients suffering CVD are lacking.