OBJECTIVES: The present study aims to answer the following questions: 1) Can the results of economic evaluations be considered transferable from France to the UK, and vice versa?; 2) What are the main reasons for any lack of transferability?; 3) What could be done, in future studies, to increase the transferability of results?; and 4) How can international databases of economic evaluations, such as the European Network of Health Economic Databases (EURONHEED), help the users of studies assess the level of generalisability in findings? METHODS: Economic evaluations covering all health technologies and involving the UK and France were located using searches of the UK’s NHS Economic Evaluation Databases (NHS EED) and the French Connaissances et Décision en ÉConomie de la Santé (CODECS) database. Studies were then analysed using an NHS EED/CODECS-specific checklist. This approach determined the degree to which results could be interpreted in the context of both countries. RESULTS: The cost-effectiveness results for France are generally more favorable than those for the UK. The main reasons for the lack of transferability are the absence of country-specific effectiveness data in multinational studies and incomplete reporting regarding cost measurements. CONCLUSIONS: Detailed reporting of study populations, costs and effectiveness data are important in assessing the transferability of the results of studies conducted in other settings. The results are informative for international databases such as EURONHEED in assessing and reporting the generalisability of economic evaluations.