OBJECTIVE: To analyze the treatment cost and cost-effectiveness of cryoplasty, a minimally invasive treatment for peripheral arterial disease (PAD), compared to angioplasty treatment in patients with Femoropopliteal Arterial Disease in the UK at 12-months. METHODS: A decision-analytic model combining clinical data from several sources on patency rates with UK unit costs for medical resources. RESULTS: The total average per patient hospital cost at 12-months were £3,433 for cryoplasty and £3,922 for angioplasty. The total cost included initial treatment cost, stenting cost post-procedure, and reintervention costs. Although the initial treatment and stenting costs with cryoplasty were higher (£2,835 vs. £2,233 for angioplasty), these costs were outweighed by the savings from lower reintervention costs of cryoplasty (£599 vs. £1,690 for angioplasty). Because cryoplasty offered improved clinical patency at a lower cost, it was a dominant treatment. CONCLUSIONS: Endovascular treatment options for patients with Femoropopliteal Arterial Disease offer a clinical alternative to surgery and, in severe cases, amputation. Cyroplasty may offer an improvement in clinical patency compared to angioplasty, and may do so at a lower cost. As these results depend on local treatment practices, centers must apply their own data to understand local impact.