OBJECTIVE:As time trade-off (TTO) and standard gamble (SG) are well-established health valuation techniques (with advantages and disadvantages), their feasibility and acceptability are important in selecting either technique for population-based health valuation studies. We therefore evaluated the feasibility, acceptability and factors influencing acceptance of TTO and SG among Chinese and Indian Singaporeans. METHODS: In in-depth interviews with adult Chinese and Indian Singaporeans (selected to represent various ages/ educational levels) conducted in English, Chinese or Tamil, respondents sorted and ranked 3 hypothetical health states using a 0-100 visual analogue scale (VAS), then generated utilities for these health states using both TTO and SG (order randomized). Respondents and interviewers evaluated (using 0-10 VAS) various aspects of these exercises. We explored associations between ethnic and sociodemographic variables and health preferences using Mann-Whitney, chi-squared tests or logistic regression analysis. RESULTS: Among 45 respondents (53% Chinese, 53% female, median age: 41 years), reported preference for TTO (n=23) or SG (n=21) was similar. Clarity and comprehension of instructions, ease of completion and amount of concentration needed were similar for both TTO and SG, with the exception of Chinese respondents' giving lower ratings for clarity of SG instructions compared to Indians (median (IQR): 8.5 (7.0, 9.0) versus 10.0 (8.5, 10.0), p=0.011). Interviewers judged that respondents had little difficulty completing, were able to understand, and required the same amount of concentration for TTO and SG, and reported that respondents easily understood and completed sorting and ranking exercises. In exploratory subgroup analysis using logistic regression, only less education was associated with preference for TTO over SG (odds ratio 5.8 (95% CI 1.05 to 32.2, p=0.044). CONCLUSIONS: Feasibility and acceptability of TTO and SG among Chinese and Indian Singaporeans are high. Although there was no preference for TTO or SG in general, TTO was preferred by subjects with less education.