OBJECTIVE: Introducing daily instead of weekly delivery of drugs and medicinal supply to hospital departments has been widely supported by Ministry of Health and Crown agency as a method for improvement of quality of drug supply and pharmacoekonomics in this field. According to published data the pharmacoeconomic consequences of this measurements could lower the drug and medicinal supply expenses for as much as 90%. In Novi Sad Clinics, Serbia and Montenegro, weekly delivery of drugs and medicinal supply is stil present. Therefore, we performed a study in order to see if a change to daily dosing, together with everyday control of structure and dose of prescribed drugs by clinical pharmacologist can rationalize dug use. METHODS: Our study with daily dosing of drugs and medicinal supply started at Urological clinic, University Teaching Hospital Novi Sad, Serbia and Montenegro. At the beginning the monthly use of drugs was followed up. The drug use was calculated using ATC/DDD classification. RESULTS: According to our expectation, financial results did show substantial lowering of the drug expenses, of 36%, with antibacterilas being the most restricted drugs, followed by local anesthetics. CONCLUSIONS: The new way of drug delivery, with every day follow up and corrections of the structure and amount of drugs prescribed by urologist significantly improved the safety and quality of the drugs. Constant monitoring in drug delivery enabled them to prevent potential clinically harmful interactions, to improve patients compliance together with substantial financial results, that support the new system of drug delivery.