OBJECTIVES: To evaluate the relation between post-stroke physical disability and place of residence (home vs long-term care facility), and, secondarily, between disability and other economic, quality of life and caregiver burden outcomes. METHODS: Randomly selected Erlangen Registry ischemic stroke patients, 18 years of age or older, still alive at least 90 days post stroke and willing to attend a study visit were administered a 30-day retrospective resource use questionnaire, the EQ-5D, the Stroke Impact Scale (SIS-16), Modified Rankin Scale (mRS), and Barthel Index; caregivers reported resource use and hours of informal care. Stroke history was obtained from registry records. Multivariate logistic and linear regressions were used to examine the associations. Preliminary results are reported for the first 200 of the planned 360 subjects. RESULTS: At a mean time post stroke of 4 years (min 0.26 - max 11.88 years), 14.5%, 25%, 25%, 13%, 7.5%, and 15% of subjects (49.5% male; mean age 74.3 years) had mRS scores of 0, 1, 2, 3, 4 and 5, respectively. At the study visit, 72% of patients were residing at home, and 28% were residing in a long-term care facility. The probability of residing in long-term care was significantly higher in patients with severe disability (mRS=3,4,5) vs mild/moderate disability (mRS=0,1,2) (adjusted for age, sex, and time since index stroke; OR=14.8, p<0.0001). Over the previous 7 days, 96% of caregivers of severely disabled subjects cared for at home vs 50% of caregivers of the mildly/moderately disabled patients at home reported =1 hour of informal care (p<0.001); mean informal care time received by patients with severe disability was 26.6 hours; patients with mild/moderate disability received 6.6 hours (p<0.001). CONCLUSION: Results suggest post-stroke impairment remains an important determinant of place of residence and caregiver burden well beyond the acute care period, outcomes which translate into significant additional costs.