OBJECTIVES:To estimate the prevalence of any type Bipolar Disorder (BP) and comorbidity burden in a Health Management Organization. METHODS: Cross-sectional assessment of the Badalona Serveis Assistencials (BSA) administrative claim database. All subjects above 15 years, both sexes, included in BSA claim database were included in the analysis. Patients with BP, diagnosed according with DSM-IV criteria formed the study cohort. The control group was formed for the rest of individuals in the BSA database without BD. Prevalence of both BP disorder and comorbidities were assessed directly. Corresponding odds ratios to measure intensity of association were computed adjusted by age by using logistic regression techniques. The following comorbidities groups were assessed: diabetes, hypertension, dyslipidemia, cancer, coronary hearth disease, cerebrovascular disease, asthma, COPD, obesity, non-dementia neurological disorders, dementia of any type, and other psychiatric disorders. RESULTS: We identified 178 subjects with BD (53.4% women, 49.9+19.2 years old, mean+SD) out of 86.028 individuals [50,5% women (p=0.494); 45.5+17.8 years (p=0.001)] in BSA database; overall prevalence = 0.21% (0.18%-0.24%), men [0.20% (0.17%-0.23%)], women [0.22% (0.19%-0.25%)]. Patients with BD showed significant higher frequency of dislipidemia [25.8% (95% confidence interval: 19.6%-32.9%) vs 16.2% (15.9%-16.5%); age adjusted OR=1.54 (1.07-2.23, p=0.021)], non dementia neurological disorders [2.2% (0.6%-5.7%) vs 0.4% (0.3%-0.4%); adjusted OR=4.17 (1.50-11.60, p=0.006)], dementia [9.0% (5.2%-14.2%) vs 0.6% (0.5%-0.7%); adjusted OR=14.00 (7.21-27.21, p<0.001)], other psychiatric disorder [23.6% (17.6%-30.5%) vs 7.9% (7.7%-8.1%); adjusted OR=3.29 (2.30-4.70, p<0.001)] and obesity [41.4% (32.3%-50.9%) vs 27.1% (26.6%-27.5%); adjusted OR=1.83 (1.24-2.68, p=0.002)]. No other significant differences could be found. CONCLUSION: The observed prevalence of Bipolar Disorders was comparable to the one observed previously in other countries. Compared with general population managed by BSA, the comorbidity burden is higher in subjects with Bipolar Disorders, mainly any type neurological disorders and other psychiatric disorder.