OBJECTIVE: The objective of this study was to determine the relationship between profile-based cancer-specific quality of life dimension scores, and Euroqol-5D scores in a breast cancer surgery sample. METHODS: Seventy-five breast cancer surgery patients participated in the study. The patients completed the Functional Living Index-Cancer(FLIC), the Functional Assessment of Cancer Therapy-General Version(FACT-G), and the Euroqol-5D(EQ-5D) at the same visit, and the order of instruments was randomized. Scores on both the EQ-5D classification system, as well as on the thermometer were obtained, and both scores were related to dimension scores on the FLIC and the FACT-G. Information on the age of the patient, the cancer stage, and the number of comorbidities was obtained through chart review. RESULTS: The mean age of patients was 60(SD=10.7). The majority of patients (96%) were diagnosed with either stage I or stage II breast cancer. Over 90% of patients had up to 3 comorbid conditions, with hypertension being the most frequent. Mean scores on the EQ-5D classification system, and the thermometer were 87.4(SD=13.6), and 86.6(SD=12.6) respectively. Ceiling effects were observed on both the classification system, and the thermometer. Both linear and double log regression results showed that quality of life dimension scores were significantly related to scores on both the EQ-5D classification system, as well as on the thermometer. FLIC dimension scores made statistically significant contributions to the EQ-5D classification score, but not to the score obtained on the thermometer. FACT-G dimension scores did not contribute significantly to either the EQ-5D classification score, or the thermometer score. CONCLUSION: The results of this study show that cancer-specific quality of life dimension scores are significantly related to Euroqol-5D scores.