OBJECTIVE: To determine the impact of pharmacist intervention on various patient outcomes. METHODS: 201 patients belonging to one medical group were divided into the experimental group (N=54) and the comparator group (N=147). 353 patients belonging to a second medical group served as the control group. All patients were sent a baseline survey and a follow-up survey after 6 months to gather data on demographics, compliance, quality of care, satisfaction with pharmacy care and disease specific quality of life. During the 6 month period, the experimental group received specialized pharmacists services, while the others received usual care. Clinical data, compliance from prescription claims and health care utilization data were collected separately. RESULTS: Patient satisfaction with pharmacy services significantly improved at follow-up for the experimental group. The increase in satisfaction at follow-up was significantly higher in the experimental group compared to the comparator as well as the control groups. HbA1c scores for diabetic patients were significantly improved in the experimental (7.8 down to 6.7) group. Adherence to some of the HEDIS guidelines was significantly higher in the experimental group compared to the comparator group. Percentage of high compliers (self-reported Morisky score) significantly doubled at follow-up in the experimental group ( 24.6% up to 52%) and percentage of low compliers significantly decreased at follow-up (73.6% down to 49.1%). Number of drug therapy problems were detected and reduced by pharmacists intervention in the experimental group. Pharmacists were also able to successfully improve patient health behaviors related to medication use in the experimental group. CONCLUSION: The pharmacists were successful in improving patient outcomes, thereby providing better patient care.