HYPERTRIGLYCERIDEMIA AND RISK OF ALL-CAUSE MORTALITY AND MAJOR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE (ASCVD) EVENTS IN CLINICAL PRACTICE- THE TG-REAL STUDY

Author(s)

Veronesi C1, Arca M2, Borghi C3, Colivicchi F4, De Ferrari G5, Desideri G6, Pontremoli R7, Temporelli P8, Perrone V1, Degli Esposti L1
1CliCon S.r.l. Health, Economics & Outcomes Research, Ravenna, Italy, 2Department of Internal Medicine and Medical Specialties, UOS Atherosclerosis Center, La Sapienza University of Rome, Roma, Italy, 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy, 4Azienda Complesso Ospedaliero “S. Filippo Neri”, Rome, Italy, 5Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 6University of L'Aquila, Department of Life, Health, and Environmental Sciences, L'Aquila, Italy, 7Department of Internal Medicine University of Genoa and IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy, 8Maugeri Foundation, IRCCS, Division of Cardiac Rehabilitation, Scientific Institute of Veruno (NO), Veruno, Italy

Presentation Documents

OBJECTIVES: The aim of this study was to assess the association between hypertriglyceridemia (HTG) and all-cause mortality and atherosclerotic cardiovascular disease (ASCVD) events in Italy.METHODS: A retrospective analysis using administrative and laboratory databases of 3 Italian Local Health Units was performed. All individuals with at least one measurement of plasma triglycerides (TG) between January 1, 2010 and December 31, 2015 were included. They were retrospectively characterized up to 12 months from the date of first TG measurement, and events occurred until December 31, 2016 were considered. Individuals were divided into 3 groups based on TG available in the follow-up period: those with normal TG (all measurements <150 mg/dl) (Reference Group), those with high TG (all measurements between 150-500 mg/dl) (Group 1) and those with very high TG (all measurements >500 mg/dl) (Group 2). Cox models were used to assess the association between HTG and events, adjusting for age, sex, previous cardiovascular hospitalizations, treatment with other drugs (statins, antihypertensives, antidiabetics, antithrombotics), total and HDL cholesterol at baseline.RESULTS:

Conference/Value in Health Info

2018-11, ISPOR Europe 2018, Barcelona, Spain

Value in Health, Vol. 21, S3 (October 2018)

Code

PCV101

Topic

Health Service Delivery & Process of Care

Topic Subcategory

Treatment Patterns and Guidelines

Disease

Cardiovascular Disorders

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