OBJECTIVES: Several instruments that measure the impact of overactive bladder (OAB) on patients' quality of life are available. However, neither the overall levels nor the multidimensional aspects of satisfaction with OAB treatment have been studied in patients living with OAB symptoms. This project aims to develop and validate an OAB specific satisfaction questionnaire, the OAB-S. METHODS: The OAB-S evaluates medication expectations (14 items), daily life with OAB (11 items), medication tolerability (7 items), medication satisfaction (16 items), and includes 3 stand-alone items that query patients on overall expectation, satisfaction, and willingness to continue treatment. The questionnaire was administered in a stand-alone validation study: the medication expectations module was administered at baseline and the other modules at week 2 and 4. Multitrait item and exploratory factor analyses were performed to assess the subscale structure. RESULTS: Preliminary results on 83 subjects indicated a low percent of missing data (<3.0%) but a high ceiling effect in the medication expectations (i.e., patients had high expectations) and in the medication tolerability modules (i.e., patients were not bothered by the medication's side effects). Internal consistency reliability of each item reached satisfactory levels (Cronbach's alpha >0.7). In addition, significantly high level of association (Pearson's correlation >0.6) were found for most of the questionnaire's items with items of related content from the SF-12, the OAB-q, a health-related quality of life questionnaire and the TSQM, a generic treatment satisfaction questionnaire. Results on the entire population (N=250 patients) will be presented. The relationship between expectation and satisfaction will be further analyzed for naïve patients (i.e., without previous experience with an OAB medication). CONCLUSION: Results demonstrated that the OAB-s is performing well with little missing data, satisfactory internal consistency and content validity. The OAB-S will offer researchers a valuable tool for measuring patient satisfaction with OAB treatment.