INTRODUCTION. Economic factors are very important in limiting therapy options for haemophilia, but inadequate treatment lead to costly consequences having a negative impact on patients' social integration AIM OF THE STUDY: to evaluate direct medical costs (therapy and hospitalization) of bleedings, secondary prophylaxis and surgical interventions; direct non-medical costs (home-hospital travel costs) and indirect costs (morbidity costs, loss of income of family members, average number of days off at scholl/work) MATERIAL AND METHOD. 224 haemophiliacs registered and treated in Haemophilia Centre Timisoara and in Clinical Centre for Evaluation and rehabilitation “Christian Serban” Buzias, followed-up during a seven-years period. 84.38% of the patients had haemophilia A and 15.62%-haemophilia B. Data were obtained from medical charts and from questionnaires administered to patients. Because in a developing country an economic analysis is difficult to ascertain, unitary costs were expressed in €, at average exchange rate commnicated by the National Romanian Bank for the last year of the study period. RESULTS. Therapy costs represented 54.56% of direct medical costs in haemophilia A patients without inhibitors, 67.13% in haemophilia B- and 87.63% in patients with high-titer inhibitors. Pseudotumour consumed the highest financial resources in haemophilia A patients and complicated haematoma was the most costly complication in haemophilia B patients. Direct non-medical costs represented important percents of mean patient and family income. Mean monthly morbidity cost was 108.28 € and loss of income of family members who forfeid employment in order to offer home care for haemophilia patients was 81.88 €/month. Average number of days off at school/work was 46.64/year, varying according to haemophilia severity. CONCLUSIONS. Inadequate resource allocation for haemophilia treatment lead to costly complications, affecting social integration and leading to important loss of income, which is responsible for a poor treatment compliance, all these factors having a strong interactions.