OBJECTIVE: To provide evidence that a heart failure (HF) disease management (DM) program can reduce disparities in healthcare outcomes in minority populations. METHODS: The study sample included HF patients who were in a nurse-mediated DM program for at least 90 days, and who had a minimum of 2 quality of life (QOL) and 2 NYHA measurements. QOL was measured for both physical (PCS) and mental health (MCS) using the SF-8 survey instrument. QOL and NYHA were measured at the time of program enrollment and quarterly thereafter. Baseline QOL and NYHA scores were compared to the most recent. The 95% confidence interval for clinical significance is +/- 6.3 for MCS and +/- 5.7 for PCS. There were 2578 patients in the sample, of which 2081 were white and 497 were black. Blacks were significantly younger than whites (67 and 72 years of age), and were more female (61% and 52%). RESULTS: The mean PCS at baseline was 38.16 and 37.96, for whites and blacks respectively. The mean PCS for the most recent scores was 41.39 (p <0.0001) and 42.01 (p <0.0001) respectively for whites and blacks. Importantly, 39% and 45% of whites and blacks had clinically significant improvements in PCS. The mean MCS at baseline was 46.44 and 47.28, for whites and black respectively. The mean MCS for the most recent score was 47.84 (p <0.0001) and 48.21 (p=0.05) respectively for whites and blacks. Twenty seven percent of both groups had clinically significant improvements in MCS. At baseline, 45% of whites and only 35% of blacks were NYHA I or II. For the current measurement 57% of whites and 59% of blacks were NYHA I or II. CONCLUSIONS: Based upon these results, DM reduces healthcare disparities between white and black populations.