ISSUE: The panel will provide an overview of benefit measures that are available for health resource allocation for children and adolescents, with a special focus of generic health state utility measurements. Methodological and empirical studies, as well as crucial technical issues (e.g. whose value to use, proxy- vs self-assess) in their application to economic evaluation targeting pediatric population will be debated. Gang Chen will review methodological issues in preference-based pediatric outcome measurement in various settings, empirical evidences from multi instruments comparisons, as well as potential supplementary roles of health state utility and subjective wellbeing measures. Ruoyan Gai will present ongoing studies to elicit preferences on different health states from adolescents for the Japanese version of the CHU9D, and provide an insight on health financing for pediatric care. Nan Luo will provide a critical perspective, by comparing different instruments and updating new developments for EQ-5D-Y, and discuss possible ways of incorporating the instruments into economic evaluation guidelines. Each panelist will speak for 15 minutes and further share his/her views with the audience in a 15-minute Q&A session. OVERVIEW: Preference-based health-related quality of life (HRQoL) instruments (or called health state utility instruments) such as the EQ-5D questionnaire has been widely used to estimate quality-adjusted life years to facilitate economic evaluation around the world. However, traditional measurements of health state utility for adults are not suitable for use in children, causing the cost-effectiveness evidence needed to inform policy making on pediatric products lagging behind. Several generic health state utility instruments have been developed for use in children and adolescents, including the Child Health Utility 9D (CHU9D) and EQ-5D Youth (EQ-5D-Y), a child friendly version of EQ-5D. Meanwhile, there is also a current trend to adopt a subjective wellbeing concept to capture much broader impact of intervention. So far, very limited empirical evidence exist regarding the usage of above benefit measures in pediatric population. A standard methodological framework also does not exist, although researchers have recognized the necessity of conducting economic evaluation in child health. This panel discussion will contribute to a crucial ongoing debate regarding technical issues for outcome measures of this vulnerable population.