OBJECTIVES: To assess the impact of pharmacist intervention on health outcomes in early detection and early prevention of patients with non-communicable diseases. METHODS: This was a prospective, interventional study conducted over a period of six months at a South Indian Community Pharmacy. Blood pressure and capillary blood glucose levels of individuals visiting the pharmacy and gave consent was recorded. Patients newly detected were counseled and referred to clinician for medical management and followed up for assessing the health outcomes. RESULTS: During the course of the study, a total of 660 individuals (males: 528, Females: 132, mean age: 44 years) were screened. Among them, 142 individuals (incidence rate: 21.5%) were newly detected (98: Diabetes and 44: hypertension) Base line fasting capillary blood glucose (FCBG) was found 138±12 mg/dl and blood pressure was 152±8mmHg systolic and 91±3mmHg diastolic. In two subsequent follow ups the FCBG was found 124±4mg/dl and 116±4mg/dl. Among patients with hypertension the mean blood pressure was found 140±3mmHg systolic and 84±3mmHg diastolic (First follow up) 134±2mmHg systolic and 81±2mmHg diastolic (final follow up). End of the study findings has shown significant (p≤0.01) improvement in achieving goal blood glucose and goal blood pressure. CONCLUSIONS: Pharmacist mediated educational intervention has shown in improvement of health outcomes in newly detected diabetes and hypertensive patients.