OBJECTIVES: Antimicrobials are among the most utilized drugs on haematological patients in most hospitals. To determine its appropriateness, a drug utilization review was conducted to provide an insight on the pattern of use, determinants of use, quality of use and outcome of use in a public hospital. METHODS: This is a descriptive study where 200 patient’s data were randomly extracted from the electronic hospital information system based on the defined inclusion criteria. Details of patient signs and symptoms and microbiological culture/sensitivity testing were retrieved by using Medication History Assessment, Pharmacotherapy Review Form, and Bed Head Ticket (BHT). Outcome is measured by examining the concordance to guidelines and DDD where the pattern and factors that influence its use. RESULTS: CONCLUSIONS: This study showed that the choice and dosing of prophylaxis antimicrobial agents in haematological patients is in accordance with their appropriate indications and standard therapy guideline.