OBJECTIVES: To assess the medication adherence and quality of life in elderly patients METHODS: It is a cross-sectional, interventional study carried out in a general medicine department of Kasturba Medical College Hospital from June 2012- April 2014. The intervention (counseled at discharge, even telephonically) & a control group (discharge counseling) was administered to three follow-ups Morisky 8 items Scale & Sf36 V2 along with a pill count. The data was subjected to descriptive statistical analysis (RM ANOVA) by using SPSS 20 vs. RESULTS: Among 495patients, 401 completed the study. In which, 325(81%) have, DM 65(16.2%), DMAKI 8(2%), DMCKD 4(1%), DM Complications other than renal 26(6.5%),, DMHTN 100(24.9%), DMHTN complication10(2.5%), HTN 103(25.7 %), HTN complication 9(2.2%). The FBS & PPBS of the mean scores were125.09+25.52, 145.92+28.04 and BP was 84.62+5.096; 132.38+11.26 . The mean MAB scores of the diseases at base line (6.68 + 0.70; 6.52 + 0.32; 7.06 + 0.44; 6.73+0.61; 6.73+0.66; 6.67+0.46 ; 6.61+0.82: 6.41+ 0.45 )& at third follow up was (7.74 + 1.02; 7.87 + 0: 7.81 + 0.08; 6.77 +1.93; 7.85+0.17; 7.75+0.16; 7.77+0.684; 7.85+0.09 ). The total QOL (PCS+MCS) score at baseline (52.61+3.5; 53.63+2.935; 54.25+2.825; 51.88+3.705; 51.51+3.79; 52.15+3.175; 52.26+3.715; 48.83+3.365) & at the third follow of the of the disease (58.31+2.735; 58.58+3.215; 60.62+0.88 ; 58.84+2.555; 59.07+2.83; 59.4+2.945 ;58.8+2.775; 57.5+2.9) also showed significant improvement.. The overall P values for the various diseases observed between p<0.01- 0.005. CONCLUSIONS: This study proposes that patient counseling service can become a complimentary for health professional and shown an enhancement in Medication Adherence Behavior and Quality of life of elderly. This study also highlights the Patient counseling is a need of the hour in developing countries