PURPOSE: To discuss the potential use, challenges, and opportunities to conduct health outcomes research using large administrative databases, and share Taiwan experiences to strengthen future research in this field.  DESCRIPTION: Taiwan has a single-payer health insurance system that covers 99.9% of its population. The National Health Insurance Research Database (NHIRD) in Taiwan is mainly used for reimbursement purposes; however this claims database can be a tool to enrich epidemiology, health services research, comparative effectiveness research, administration, and payment policy. Study findings from this database could be applicable to other Asian countries for market access purposes. This workshop, led by health outcomes researchers who have hands-on experiences with different large administrative databases, will provide an array of knowledge and advice for conducting related studies in Taiwan. Topics in the workshop will include: 1) an overview of NHIRD including database content, structure, and related data use regulations, 2) our experience of using data to support reimbursement and outcomes research issues using NHIRD, and 3) examples of potential benefits of using the NHIRD to demonstrate how this database could facilitate global-to-local adaptation projects such as future trial designs and evidence-based health technology assessments. Workshop participants will receive comprehensive knowledge about the NHIRD and learn the potential challenges, limitations, and opportunities in using this administrative database.