OBJECTIVES: To determine the risk factors influencing cardiovascular disease in indian (non-smoking and non-alcoholic) women with Type 2 Diabetes Mellitus (T2DM). METHODS: This was a retrospective case- control study on T2DM female who was diagnosed during 2010-2015 presenting to a tertiary care hospital. Risk factors leading to cardiovascular (CV) primary event were identified. RESULTS: Of the 150 cases presented with chest pain, breathlessness or for cardiac evaluation and 280 controls presented with non-cardiac complaints (fever, headache, abdominal pain etc ) mean age for cases was 63.02 (±9.228) and for control was 55.85 (±11.870) . BMI for cases (37.2% were overweight , 9.6% obese) was more as compared to controls. 89.1% of cases were on mixed diet and 10.9% were purely vegetarian whereas 50.0% of controls were on mixed diet and 50.0% were purely vegetarian . Duration of diabetes greater than 5 years for cases was 80.7% and for controls was 65.4%. Duration of hypertension greater than 5 years for cases was 79.2% and for controls was 57.0%. Mean total cholesterol for cases is 180.01 and for controls is 172.49. 45.3% of cases were on sulfonylureas and 26.4% of controls were on sulfonylureas. CONCLUSIONS: The risk factors influencing Cardiovascular Disease in Indian(non-smoking and non-alcoholic ) women with T2DM are advancing age , BMI more than normal ,women on mixed diet, with duration of diabetes and hypertension more than 5 years. Women on Sulfonylureas have more risk of developing cardiovascular disease. There are limited studies reported on primary CV event in Indian diabetic women’s associated risk factors comparable to those very well established in men. Apart from establishing western population’s risk factors there are a sizable portion who are vegetarians, with no ECG abnormalities and who need a better post-menopausal glycemic control strategy.