PRODUCTIVITY LOSS OF RHEUMATOID ARTHRITIS PATIENTS BY THEIR LEVEL OF DISEASE ACTIVITY SCORE
Author(s)
Bae S1, Koh H2, Kim Y2
1Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Pfizer Pharmaceuticals Korea Limited, Seoul, South Korea
OBJECTIVES: To identify productivity loss of Rheumatoid Arthritis (RA) patients with different levels of disease activity score (DAS). METHODS: Data were abstracted from the outcomes research of 2,000 RA patients. In this study, 1,457 RA patients who had DAS recorded in the medical charts were analyzed. RA patients age > 20, treated with DMARDs for at least six months, and signed informed consent were enrolled in this non-interventional, multicenter, cross-sectional observational study from December 2012 to June 2013. Productivity loss was estimated with The World Health Organization Health and Work Performance Questionnaire (HPQ) in terms of time and indirect cost. DAS was defined using 28 joints with erythrocyte sedimentation rate (ESR). Baseline characteristics of RA patients and productivity loss outcomes were compared by DAS groups using analysis of variance. RESULTS: Of all RA patients with DAS, 84% were females, 54% had low DAS (DAS-28-ESR < 3.2), 38% and 7.6% had moderate (DAS-28-ESR 3.2-5.1) and high DAS (DAS-28-ESR > 5.1), respectively. Patients with moderate to high DAS had increasingly higher LPT and indirect costs than those with low DAS (Time in hours: 110.0±58.4, 132.4±57.2 vs. 71.5±52.0, p<0.001; Indirect costs in 1,000 KRW: 1,097±607, 1,302±554 vs. 741±531, p<0.001). In multivariate regression analyses, significant positive associations with high LPT were shown in high (adjusted OR = 6.16, 95% CI: 3.6-10.5) and moderate DAS (adjusted OR = 2.63, 95% CI: 2.01-3.44) compared to low DAS. Also, significant positive associations with high monthly cost of LPT were shown in high (adjusted OR = 5.58, 95% CI: 3.35-9.30) and moderate DAS (adjusted OR = 2.65, 95% CI: 2.03-3.45) compared to low DAS. CONCLUSIONS: Patients with higher DAS appeared to have worse productivity loss outcomes. Early strategic therapeutic approach for RA patients with moderate to high DAS showing strong associations with high productivity loss is needed to minimize socio-economic burdens.
Conference/Value in Health Info
2016-09, ISPOR Asia Pacific 2016, Singapore
Value in Health, Vol. 19, No. 7 (November 2016)
Code
PMS16
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Musculoskeletal Disorders