OBJECTIVES: In this era of patient empowerment, patients’ feedbacks about healthcare providers and services which reflect the quality of care are provided through the internet. Likewise, well-compiled patient reports of medication experience (PROME) available through a web portal could have great potential to advance the patient-centered practice. However, what patients’ reported medication experience means to patient care has not been studied. In this study, we examined older adults’ perceptions on the healthcare applicability of, the reporting items included in, and the sponsorship of a hypothetical PROME.  METHODS: We used a cross-sectional survey to examine participants’ perceptions of a hypothetical PROME. Between August and December of 2013, 300 members of seven senior centers in a metropolitan area of a Southeastern state of the United States were recruited to participate in the survey. Those who completed the survey received a $20 grocery gift card. RESULTS: An overwhelming majority of study participants (81%) had a favorable perception of the PROME’s healthcare applicability. They were mostly positive that the PROME would facilitate patient-physician communication except for the perception (44.3%) that physicians would be upset with the mention of PROME. Further, 85.7% of participants considered the PROME information trustworthy and 72% were willing to participate by reporting their own medication experiences. Study participants wanted the PROME to report the number of reviews, star ratings and individual comments concerning different medication attributes such as side effects (28%), cost (21%) and effectiveness (19%). Finally, the PROME sponsorship was important to participants, with the most trusted sponsor being “academic institutions (30%).” CONCLUSIONS: Survey participants believed PROMEs provide useful and credible information to facilitate patient-physician communication, and were willing to participate in reporting their medication experiences. Academic institutions were the most trusted sponsors of PROMEs.  Acknowlegement: Authors thank the SNU Research Institute of Pharmaceutical Sciences for its research support.