OBJECTIVES: Infections are the major reason for the poor prognosis of a condition. Control on infections can be achieved by usage of antibiotics. Just like a coin have two sides; antibiotics also have two sided effects. One is control on infection; the other is resistance to an organism. From a decade, problem of resistance is arising. Drug utilization evaluation is a tool to improve the rationality in prescribing i.e., it helps in monitoring the drug efficacy, cost constraints and other factors related to patient safety. Our present study aims in accessing the drug utilization evaluation of antibiotic usage in a tertiary care hospital which helps in accessing rationality. METHODS: A prospective study was conducted for a period of four months from September 2015 to December 2015 in Medicine department of Viswabarathi Hospital, Kurnool, AP. RESULTS: A total of 210 prescriptions were analyzed. Among the wide range of antibiotics ie., 479 antibiotics prescribed, beta-lactams were found in the maximum cases which accounts for more than half of the cases. 51.90% i.e. a little more than half of the prescriptions were with two antibiotics, followed by three antibiotic prescriptions. 9.05% prescriptions were with 4-5 antibiotics. CONCLUSIONS: Judgemental use of antibiotics will reduce the burden of multi-drug resistance and thereby enabling better patient management and limiting the resultant morbidity and mortality.