OBJECTIVES: The current study design to assess patient’s attitude towards Deprescribing in Quetta, Pakistan  METHODS: A Cross sectional study was conducted to assess patient's attitude towards deprescribing. Data was collected from Government hospitals namely Bolan medical Complex and Sandeman Provincial Hospital and from community pharmacy from July to October 2015. Patients were interviewed, asked and guided to fill the Patient Attitude towards Deprescribing questionnaire. Total 207 sample was collected. Participants’ responses and attitudes toward Deprescribing were analyzed, SPSS 20 was used for Descriptive analysis to demonstrate patients’ demographics and inferential statistics have been done. RESULTS: Result showed that majority of respondents 162 (78.3%) were between 28-67 years. One hundred and eighty respondents (87%) were married. Majority of respondents were educated 133 (64.25%), Sixty (29%) were private servant with majority (n=50, 24.2%) having monthly income more than Pk.Rs. 30000. Around 54.6% patients showed positive attitude toward deprescribing. Age had a significant influence on the positive attitude (p = 0.001, whereas, total number of daily medications, and discount on medication did not influence willingness to deprescribing the medication.  CONCLUSIONS: The study concluded that patient had positive attitude toward deprescribing, older people had more tendency towards it. Patients should be educated continuously so that they can build trust prescription medicines prescribed by physician.