OBJECTIVES: This study aimed to assess the knowledge and practice of foot care in Diabetes mellitus (DM) patients among two different Government hospitals and general community of Quetta city, Pakistan METHODS: A cross-sectional study was conducted in two government hospitals and general population of diabetic patients and about 400 questionnaires were distributed among patients. Data gathered from April to September 2015. Pretested questionnaire was used to assess the knowledge and practice of diabetic patients regarding foot care. The knowledge and practice score were classified as adequate if score >50% and poor if score was <50%. Descriptive and inferential statistics have been done by using SPSS version 20. RESULTS: Out of 400 questionnaires, 364 were returned (response rate 91%). Majority (n=112, 30.8%) of respondents were between 46-55 years. Male gender was dominating (n=204 ,56.0%) with 323 (88.7%) were married. Majority of respondents were from urban locality 269 (73.9%). Majority of respondents 80 (22.0%) were educated but majority (n=168 ,46.2%) were having no job. Large number of respondents 58.8% had adequate knowledge and 62.4% had poor practice of DM foot care. Demographic characteristics Locality, Level of education, Occupation and income (p < 0.001) had statistically significance association with knowledge and practice score. CONCLUSIONS: The result of study shows adequate knowledge and poor practice among Diabetic patients regarding foot care, betterment of knowledge is necessary to enhance overall practice and to reduce diabetes foot complications.