OBJECTIVES: To examine demographic and socioeconomic factors associated with hospitalizations due to mental disorders among Asians in the Kansas City metropolis (Missouri, U.S.) from 2004 to 2013. METHODS: This was a retrospective study using the Missouri Hospital Discharge Data and American Community Survey. Mental disorders were identified by ICD-9 codes 290.0-290.9, 292.0-302.9, and 305.1-319.9. Missouri Hospital Discharge Data provided hospitalizations (yes/no) due to mental disorders according to zip codes. American Community Survey provided median annual income (<$50,000 or ≥$50,000), proportion of high school graduates or higher (<30% or ≥30%), proportion of those who were foreign born (<1% or ≥1%), proportion of those who were unemployed (<5% or ≥5%), sex, and age (<65 or ≥65 years old) according to zip codes. The zip codes of nine counties in the Kansas City metropolis were included. A multiple logistic regression was conducted, in which hospitalization was the dependent variable, and the other variables were independent variables. RESULTS: Asians had 10,780 hospitalizations due to all causes and 366 hospitalizations due to mental disorders from 2004 to 2013. Asians had a higher rate of hospitalizations due to mental disorders, 194 per 100,000, compared with Caucasians (120 per 100,000) and African Americans (140 per 100,000). Female sex (OR: 1.41; 95% CI: 1.13, 1.74), <65 years of age (OR: 1.80; 95% CI: 1.28, 2.52), and residence within zip codes of median annual income <$50,000 (OR: 1.41; 95% CI: 1.08, 1.86) predicted hospitalizations. CONCLUSIONS: Among Asians, women, those <65 years of age, and those living in less affluent areas were at highest risk for hospitalizations due to mental disorder. These factors suggest greater stress and limited resources for supporting mental health. Health care providers are encouraged to monitor mental health and stressors in these patients.