OBJECTIVES: The main objective of the present study focuses on evaluation of physical, psychological and social aspects of health related quality of life in Diabetic Mellitus patients in representative sample population. METHODS: The study consisted of a representative population sample of 325 out-patients with diabetes mellitus. The prospective study was carried out for a period of one year at tertiary care hospital, Warangal. Data was obtained using different sources and patients were interviewed to identify health related quality of life (HRQOL) using 3 modified questionnaires “SF-36 WHO wellbeing questionnaire, Quality of life enjoyment and satisfaction questionnaire, Diabetes specific quality of life scale questionnaire”. These modified questionnaire includes domains like emotional wellbeing, functional wellbeing, physical wellbeing, social/family wellbeing, diabetic specific goals and satisfaction on blood glucose values, burdens and restrictions from diabetes and its treatment. RESULTS: In the present study, the HRQOL is categorised as high, moderate and low. Overall patients are 325, among them 260 were adults and 65 were geriatrics further 152 were male, 173 were female. In reference with WHO wellbeing scale, 15% adults, 3% geriatrics shared high HRQOL, 62% Adults, 40% geriatrics shared moderate HRQOL and 23% adults, 57% geriatrics shared low HRQOL. Based on enjoyment and satisfaction scale 88% adults, 63% geriatrics shared high HRQOL. In reference with Diabetic Specific scale 97% adults and 95% geriatric shared moderate HRQOL. CONCLUSIONS: Domains of HRQOL of diabetic patients was found to be affected moderately so it requires careful management of Diabetes Mellitus. Self-perceived health status was the main predictive factor influencing the overall HRQOL.