OBJECTIVES: The present study was designed to evaluate the drug utilization pattern of anti-hypertensive drugs and its possible efficacy on high blood pressure in patients admitted in the outpatient ward. METHODS: A prospective observational research conducted during September 2014 and F2015 February. Medical records of 206 patients aged 40-91 (mean: 59.89±10.25) years, with male to female ratio of 1.51 : 1 were randomly selected. Information on anti-hypertensive prescriptions was recorded and analyzed by using Student’s t- test RESULTS: Out of 206 patients studied, 51% (105) were on monotheraphy and 49 % ( 101) on combination therapy. Of the patients on combination therapy, 46.60% (96), 1.94 %( 4) and 0.485 % (1) were on 2, 3, and 4 drugs, respectively. Calcium channel blockers were the most frequently prescribed drug either as a single agent (29.12%) or as combination therapy (76.23%). There is no significant difference of mean reduction in both systolic and diastolic blood pressures in patients on Angiotensin II receptor blockers, Calcium channel blockers, selective  Beta blockers in monotherapy (F Value =3; P Value =0.33 for both systolic and diastolic BP, respectively). Mean reductions in both Systolic and Diastolic blood pressures were more in patients enrolled on combination therapy than those on monotherapy (t=4 and P value =0.0234 for both   systolic and diastolic blood pressures). Blood pressure control rate was 64.56%. CONCLUSIONS:   Patients on combination therapy had significantly higher reduction in blood pressures than those on monotherapy and the study demonstrated that there is no significant difference in efficacy with monotherapy of Angiotensin II receptors blockers, Calcium channel blockers, Beta blockers in blood pressure lowering effect in the study population. The prescribing pattern of physicians is in compliance with the Joint National Committee (JNC-VIII) guidelines. Major limitation of this work is the inability to determine the actual patients’ adherence to drug therapy.