OBJECTIVES::  To compare Latin America (LA) with other countries economic evaluation studies of screening strategies for cervical cancer prevention that used a Markov model to simulate the natural history of disease. METHODS:: A systematic review was conducted through searching in Medline (via PubMed), NHS EED (via CRD), Embase and Web of Science databases to identify Markov model-based economic evaluation of cervical cancer prevention strategies. This review included articles that were completed research papers, full economic evaluation of cervical cancer screening strategies and published until August 2015. The methodology for the quality reporting was assessed using some items of the Phillips 2006 and Ramos 2015 checklists. Two independent reviewers selected studies, extracted data, and assessed the quality reporting. Disagreements were resolved by consensus or arbitrage. We investigated the differences between studies conducted in LA and other countries. RESULTS:: Thirty-eight studies were reviewed. Among them, only five were conducted in LA countries. The quality reporting appraisal, in general, shows that LA studies reported less checklists’ items than the other studies, where the maximum was 53% versus 72%. The same happened with the analysis by model’s structure (78% versus 89%) and data issues (40% versus 67%). The 100% of model’s consistency was satisfied by only one LA study. CONCLUSIONS:: This systematic review shows that there is great variability in the methodology adopted for the Markov models. The quality appraisal identified that the model’s structure and the underpinning assumptions are not always clearly presented, mainly for LA countries studies.