SYSTEMATIC REVIEW OF ECONOMIC EVALUATION STUDIES FOR DENGUE VACCINE- HOW VALID ARE THE RESULTS?
Author(s)
De Soarez PC1, Silva AB1, Randi BA1, Novaes HM2, Sartori AM3
1Sao Paulo University, São Paulo, Brazil, 2Universidade de São Paulo, Sao Paulo, Brazil, 3Universidade de Sao Paulo, São Paulo, Brazil
OBJECTIVES:: To review the literature on economic evaluation of dengue vaccination to produce evidence to support a local cost-effectiveness study and to subsidize the decision to introduce a dengue vaccine in the Brazilian National Immunization Program (NIP). METHODS:: We systematically searched multiple databases (MEDLINE (via PubMed), EMBASE, SCOPUS, NHS Economic Evaluation Database (NHS EED), HTA Database (via Centre for Reviews and Dissemination - CRD) and LILACS), selecting full HEEs of dengue vaccine. Two independent reviewers screened articles for relevance and extracted the data. The methodology for the quality reporting was assessed using CHEERS checklist. We performed a qualitative narrative synthesis. RESULTS:: Eight studies were reviewed. They were conducted in Asian and Latin America countries. All studies were favorable to the incorporation of the vaccine. However, the values and assumptions assumed for vaccine efficacy, safety and duration of protection, as well as the choice of the study population and the type of model used in the analyses, associated to an insufficient reporting of the methodological steps, affect the validity of the studies results. The quality reporting appraisal showed that the majority of the studies reported less than 50% of the CHEERS checklists’ items. CONCLUSIONS:: This systematic review shows that the economic evaluation of dengue vaccination are not adherent to key recommended general methods for economic evaluation. The presented cost-effectiveness results should not be transferred to other countries. It is recommended to conduct studies with local epidemiological and cost data, as well as assumptions about vaccination that reflect the results observed in clinical trials.
Conference/Value in Health Info
2017-09, ISPOR Latin America 2017, Sao Paulo, Brazil
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PIN33
Topic
Economic Evaluation
Topic Subcategory
Cost-comparison, Effectiveness, Utility, Benefit Analysis
Disease
Infectious Disease (non-vaccine)