OBJECTIVES:: To identify and report ADR; and to assess the incidence of polypharmacy and comorbidities. METHODS:: The study was conducted at medicine departments of Academy of Medical Sciences, a tertiary care centre and a 1200 bedded teaching hospital during a period of two months . Patient above 60 years were included and; patient below 60 years, patients with intentional or accidental poisoning, patients who developed an ADR during transfusion of blood or blood products, patients with drug abuse and patients with accidental or emergency cases were excluded. Medical staff, medical post graduates, nursing staff and patients were educated and encouraged to report ADRs by creating awareness through brief presentations and conducting clinical meetings. The reported suspected ADRs were classified according to Wills and Brown classification and causality assessment done by WHO and Naranjo’s scale. RESULTS:: A total of 102 geriatric patients admitted in period of 3 months. Out of this, 65 patients were monitored. 66.15% were female and 33.84% male. 70.765% patients had diabetes, followed by hypertension 35.38%, kidney disease 35.38%, CAD 20%, CVA 18.46%, COPD 10.76%, Anemia 9.23%, Seizure 7.69%, Tuberculosis 6.3%, Thyroid problem 3.07%. 27 ADR were reported and 40% ADR are preventable. The ADR in geriatric population mostly affected gastrointestinal system (36%) and skin (18). Causality assessment shows 55.5% possible and 26.6 % were Probable. CONCLUSIONS:: The available data suggest that a scope of closer pharmacovigilance studies are much needed in the older age group due to co morbidity, which can cause ADR that are preventable.